Article
Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells.
Nucleic acids research - 1 Apr 2013
Feldmann Radmila, Fischer Cornelius, Kodelja Vitam, Behrens Sarah, Haas Stefan, Vingron Martin, Timmermann Bernd, Geikowski Anne, Sauer Sascha
Abstract excerpt
Increased physiological levels of oxysterols are major risk factors for developing atherosclerosis and cardiovascular disease. Lipid-loaded macrophages, termed foam cells, are important during the early development of atherosclerotic plaques. To pursue the hypothesis that ligand-based modulation of the nuclear receptor LXRα is crucial for cell homeostasis during atherosclerotic processes, we analysed genome-wide...
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