Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.

Dementia and geriatric cognitive disorders - 1 Jan 2006

Koivisto Anne M, Helisalmi Seppo, Pihlajamaki Jussi, Hiltunen Mikko, Koivisto Keijo, Moilanen Leena, Kuusisto Johanna, Helkala Eeva-Liisa, Hanninen Tuomo, Kervinen Kari, Kesaniemi Y Antero, Laakso Markku, Soininen Hilkka

Abstract excerpt

Alzheimer's disease (AD), especially late-onset AD (LOAD), is a complex disease. To date, the only established genetic risk factor for LOAD is apolipoprotein E (APOE) epsilon4, which explains partially the risk of the disease and modifies the age of onset. Peroxisome proliferator-activated receptor gamma (PPARgamma) regulates the transcription of BACE1 as well as inflammatory responses in the brain and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Apolipoprotein E4

Share to Finland

Share to Neuropsychological Tests

Share to Polymorphism, Genetic

Share to PPAR gamma

Source

Identifiers

PMID: 16988505
DOI: 10.1159/000095857

Genes

APOE
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.PMID 16988505Read ↗

Influence of the Pro12Ala polymorphism of PPAR-gamma on age at onset and sRAGE levels in Alzheimer's disease.Semantic proximity Read ↗

APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk.Semantic proximity Read ↗

The peroxisome proliferator-activated receptor gamma (PPAR-gamma2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians.Semantic proximity Read ↗

Gene- Gene Interaction between PPARG and APOE Gene on Late-Onset Alzheimer's Disease: A Case- Control Study in Chinese Han Population.Semantic proximity Read ↗

Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes.Semantic proximity Read ↗

Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients.Semantic proximity Read ↗

Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease.Semantic proximity Read ↗

PPARγ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

Influence of lysosomal acid lipase polymorphisms on chromosome 10 on the risk of Alzheimer's disease and cholesterol metabolism.Semantic proximity Read ↗

Gene- gene interaction between CYP2J2 and PPAR -γ gene on late-onset Alzheimer's disease in the eastern Chinese Han population.Semantic proximity Read ↗

The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association.Semantic proximity Read ↗

Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.