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Article

Improved insulin sensitivity after treatment with PPARγ and PPARα ligands is mediated by genetically modulated transcripts.

Pharmacogenetics and genomics - 1 Jul 2012

Rasouli Neda, Kern Philip A, Elbein Steven C, Sharma Neeraj K, Das Swapan K

Abstract excerpt

OBJECTIVES: We aimed to define the effects of peroxisomal proliferator-activated receptor γ (PPARγ) and PPARα agonist mono and combination therapy on adipose tissue and skeletal muscle gene expression in relation to insulin sensitivity. We further investigated the role of genetic polymorphisms in PPAR ligand-modulated genes in transcriptional regulation and glucose homeostasis. MATERIALS AND METHODS: Genome-wide...

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Identifiers

PMID: 22437669
DOI: 10.1097/FPC.0b013e328352a72e
PMCID: PMC3376224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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