Article
Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations.
Journal of human genetics - 1 Jul 2023
Krishnan Mohanraj, Phipps-Green Amanda, Russell Emily M, Major Tanya J, Cadzow Murray, Stamp Lisa K, Dalbeth Nicola, Hindmarsh Jennie Harré, Qasim Muhammad, Watson Huti, Liu Shuwei, Carlson Jenna C, Minster Ryan L, Hawley Nicola L, Naseri Take, Reupena Muagututi'a Sefuiva, Deka Ranjan, McGarvey Stephen T, Merriman Tony R, Murphy Rinki, Weeks Daniel E
Abstract excerpt
The fat mass and obesity associated (FTO) locus consistently associates with higher body mass index (BMI) across diverse ancestral groups. However, previous small studies of people of Polynesian ancestries have failed to replicate the association. In this study, we used Bayesian meta-analysis to test rs9939609, the most replicated FTO variant, for association with BMI with a large sample (n = 6095) of Aotearoa...
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