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Article

CREBRF variant increases obesity risk and protects against diabetes in Samoans.

Nature genetics - 30 Aug 2016

Loos Ruth J F

Abstract excerpt

A genome-wide study in Samoans has identified a protein-altering variant (p.Arg475Gln) in CREBRF as being associated with 1.3-fold increased risk of obesity and, intriguingly, 1.6-fold decreased risk of type 2 diabetes. This variant, which is common among Samoans (minor allele frequency = 26%) but extremely rare in other populations, promotes fat storage and reduces energy use in cellular models.

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Source

Identifiers

PMID: 27573685
DOI: 10.1038/ng.3653

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CREBRF variant increases obesity risk and protects against diabetes in Samoans.PMID 27573685Read ↗

A thrifty variant in CREBRF strongly influences body mass index in Samoans.Semantic proximity Read ↗

A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants.Semantic proximity Read ↗

Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort.Semantic proximity Read ↗

A murine model of the human CREBRF <sup>R457Q</sup> obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stressSemantic proximity Read ↗

The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans.Semantic proximity Read ↗

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.Semantic proximity Read ↗

A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations.Semantic proximity Read ↗

Gestational Diabetes - Risk Factors and Outcomes among American Samoan Women (GROW): A Longitudinal Cohort Study ProtocolSemantic proximity Read ↗

A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.Semantic proximity Read ↗

Characterization of sleep apnea among a sample of adults from SamoaSemantic proximity Read ↗

The Role of Mammalian Creb3-Like Transcription Factors in Response to NutrientsSemantic proximity Read ↗

GOAT rs10096097 and CREB1 rs6740584 single nucleotide polymorphisms are associated with type 2 diabetes mellitus in Egyptians.Semantic proximity Read ↗

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