The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition.

doi:10.1016/j.molmet.2022.101464

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Article

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition.

Molecular metabolism - 1 May 2022

Lee Kate, Vakili Sanaz, Burden Hannah J, Adams Shannon, Smith Greg C, Kulatea Braydon, Wright-McNaughton Morag, Sword Danielle, Watene-O'Sullivan Conor, Atiola Robert D, Paul Ryan G, Plank Lindsay D, Kallingappa Prasanna, King Frances, Wilcox Phillip, Merriman Tony R, Krebs Jeremy D, Hall Rosemary M, Murphy Rinki, Merry Troy L, Shepherd Peter R

Abstract excerpt

OBJECTIVE: The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples of the Pacific islands (including New Zealand Māori and peoples of Polynesia), with a frequency of up to 25% in these populations. This allele associates with a large increase in body mass index (BMI) but with significantly lower risk of type-2 diabetes (T2D). It remains unclear whether the...

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PMID: 35218947
DOI: 10.1016/j.molmet.2022.101464
PMCID: PMC8927835

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The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition.PMID 35218947Read ↗

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body compositionSemantic proximity Read ↗

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