Article
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
Cancer research - 15 Jan 2013
Jin Genglin, Reitman Zachary J, Duncan Christopher G, Spasojevic Ivan, Gooden David M, Rasheed B Ahmed, Yang Rui, Lopez Giselle Y, He Yiping, McLendon Roger E, Bigner Darell D, Yan Hai
Abstract excerpt
Point mutations at Arg132 of the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase 1 (IDH1) occur frequently in gliomas and result in a gain of function to produce the "oncometabolite" D-2-hydroxyglutarate (D-2HG). The mutated IDH1 allele is usually associated with a wild-type IDH1 allele (heterozygous) in cancer. Here, we identify 2 gliomas that underwent loss of the wild-type IDH1 allele but retained the...
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