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Article

DSCAM Mutation Impairs Motor Cortex Network Dynamic and Voluntary Motor Functions.

Cerebral cortex (New York, N.Y. : 1991) - 1 Jun 2019

Laflamme Olivier D, Lemieux Maxime, Thiry Louise, Bretzner Frédéric

Abstract excerpt

While it is well known that netrin-1 and its receptors UNC5 and UNC40 family members are involved in the normal establishment of the motor cortex and its corticospinal tract, less is known about its other receptor Down syndrome cell adherence molecule (DSCAM). DSCAM is expressed in the developing motor cortex, regulates axonal outgrowth of cortical neurons, and its mutation impairs the dendritic arborization of...

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Identifiers

PMID: 29718256
DOI: 10.1093/cercor/bhy097

Genes

DSCAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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