Article
Genetic features of multicentric/multifocal intramucosal gastric carcinoma.
International journal of cancer - 15 Oct 2018
Mizuguchi Aya, Takai Atsushi, Shimizu Takahiro, Matsumoto Tomonori, Kumagai Ken, Miyamoto Shin'ichi, Seno Hiroshi, Marusawa Hiroyuki
Abstract excerpt
Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. The genetic basis of multiple tumorigenesis in the inflamed stomach, however, is not well...
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