Article
Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Sept 2018
Sugai Tamotsu, Eizuka Makoto, Arakawa Noriyuki, Osakabe Mitsumasa, Habano Wataru, Fujita Yasuko, Yamamoto Eiichiro, Yamano Hiroo, Endoh Masaki, Matsumoto Takayuki, Suzuki Hiromu
Abstract excerpt
BACKGROUND: We attempted to identify the molecular profiles of gastric intramucosal neoplasia (IMN; low-grade dysplasia, LGD; high-grade dysplasia, HGD; intramucosal cancer, IMC) by assessing somatic copy number alterations (SCNAs) stratified by microsatellite status (microsatellite stable, MSS; microsatellite instable, MSI). Thus, microsatellite status was determined in 84 tumors with MSS status and 16 tumors...
Topics
- Aged
- Aged, 80 and over
- Class I Phosphatidylinositol 3-Kinases
- Cluster Analysis
- DNA Copy Number Variations
- DNA Methylation
- Female
- Gastric Mucosa
- Genome-Wide Association Study