Double KRAS and BRAF Mutations in Surgically Treated Colorectal Cancer Liver Metastases: An International, Multi-institutional Case Series.

doi:10.21873/anticanres.12535

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Article

Double KRAS and BRAF Mutations in Surgically Treated Colorectal Cancer Liver Metastases: An International, Multi-institutional Case Series.

Anticancer research - 1 May 2018

Deshwar Amar, Margonis Georgios Antonios, Andreatos Nikolaos, Barbon Carlotta, Wang Jaeyun, Buettner Stefan, Wagner Doris, Sasaki Kazunari, Beer Andrea, Løes Inger Marie, Pikoulis Emmanouil, Damaskos Christos, Garmpis Nikolaos, Kamphues Karsten, He Jin, Kaczirek Klaus, Poultsides George, Lønning Per Eystein, Mischinger Hans Joerg, Aucejo Federico N, Kreis Martin E, Wolfgang Christopher L, Weiss Matthew J

Abstract excerpt

BACKGROUND: While previously believed to be mutually exclusive, concomitant mutation of Kirsten rat sarcoma viral oncogene homolog (KRAS)- and V-raf murine sarcoma b-viral oncogene homolog B1 (BRAF)-mutated colorectal carcinoma (CRC), has been described in rare instances and been associated with advanced-stage disease. The present case series is the first to report on the implications of concurrent KRAS/BRAF...

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PMID: 29715113
DOI: 10.21873/anticanres.12535

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BRAF
KRAS

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