The Coexistence of RAS and BRAF Mutations in Metastatic Colorectal Cancer: A Case Report and Systematic Literature Review.

doi:10.15403/jgld-1003

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Article

The Coexistence of RAS and BRAF Mutations in Metastatic Colorectal Cancer: A Case Report and Systematic Literature Review.

Journal of gastrointestinal and liver diseases : JGLD - 3 Jun 2020

Afrăsânie Vlad-Adrian, Gafton Bogdan, Marinca Mihai Vasile, Alexa-Stratulat Teodora, Miron Lucian, Rusu Cristina, Ivanov Anca-Viorica, Balan Gheorghe G, Croitoru Adina-Emilia

Abstract excerpt

BACKGROUND AND AIMS: The coexistence of RAS and BRAF mutations is extremely rare, occurring in approximately 0.05% of patients with metastatic colorectal cancer (mCRC). Starting from a case presentation, this review aims to examine the prevalence, clinical, histopathological and molecular features of tumors with concomitant mutations. METHODS: Case report and systematic review. We performed a systematic...

Topics

Adenocarcinoma
Antineoplastic Protocols
Colorectal Neoplasms
Female
GTP Phosphohydrolases
High-Throughput Nucleotide Sequencing
Humans
Liver Neoplasms
Lung Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Middle Aged

Mutation

Neoplasm Metastasis

Neoplasm Staging

Pharmacogenomic Testing

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed

Identifiers

PMID: 32530992
DOI: 10.15403/jgld-1003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-32530992-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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