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Article

A microtubule polymerase is required for microtubule orientation and dendrite pruning in Drosophila.

The EMBO journal - 18 May 2020

Tang Quan, Rui Menglong, Bu Shufeng, Wang Yan, Chew Liang Yuh, Yu Fengwei

Abstract excerpt

Drosophila class IV ddaC neurons selectively prune all larval dendrites to refine the nervous system during metamorphosis. During dendrite pruning, severing of proximal dendrites is preceded by local microtubule (MT) disassembly. Here, we identify an unexpected role of Mini spindles (Msps), a conserved MT polymerase, in governing dendrite pruning. Msps associates with another MT-associated protein TACC, and both...

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Identifiers

PMID: 32267553
DOI: 10.15252/embj.2019103549
PMCID: PMC7232011

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