Article
Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices.
Archives of otolaryngology--head & neck surgery - 1 Feb 2009
Lohavanichbutr Pawadee, Houck John, Fan Wenhong, Yueh Bevan, Mendez Eduardo, Futran Neal, Doody David R, Upton Melissa P, Farwell D Gregory, Schwartz Stephen M, Zhao Lue Ping, Chen Chu
Abstract excerpt
OBJECTIVE: To study the difference in gene expression between human papillomavirus (HPV)-positive and HPV-negative oral cavity and oropharyngeal squamous cell carcinoma (OSCC). DESIGN: We used Affymetrix U133 plus 2.0 arrays to examine gene expression profiles of OSCC and normal oral tissue. The HPV DNA was detected using polymerase chain reaction followed by the Roche LINEAR ARRAY HPV Genotyping Test, and the...
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