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Genetic Susceptibility of Vitamin D Receptor Gene Polymorphisms on Autosomal Recessive Primary Microcephaly Patients in Pakistani Population: A Case-Control and In-Silico Study

2023-05-05

Abstract excerpt

<h4>Background: </h4> Autosomal recessive primary microcephaly (MCPH) is a rare genetic disorder that leads to reduced cerebral cortex caused by a mutation in corticogenesis. The expression of the Vitamin D receptor (VDR) gene is involved in the proliferation and differentiation of neural stem cells, and VDR polymorphisms have been associated with various neurological disorders. However, their relationship with MC...

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Literature Corpus work: c2501e33-1551-588e-9464-5bfa511676c0
DOI: 10.21203/rs.3.rs-2862919/v1

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