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Article

A novel mutation in the TUBB8 gene is associated with complete cleavage failure in fertilized eggs.

Journal of assisted reproduction and genetics - 1 Jul 2018

Yuan Ping, Zheng Lingyan, Liang Hao, Li Yu, Zhao Haijing, Li Ruiqi, Lai Luhua, Zhang Qingxue, Wang Wenjun

Abstract excerpt

PURPOSE: Cleavage of the zygote during human reproduction is a key event of early embryonic development. The genetic events associated with idiopathic embryonic cleavage failure are not certain. Mutations in the tubulin beta 8 class VIII (TUBB8) gene have been reported to be associated with oocyte maturation, fertilization, and developmental arrest. Here, we aimed to assess the clinical and genetic...

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Source

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Identifiers

PMID: 29704226
DOI: 10.1007/s10815-018-1188-3
PMCID: PMC6063842

Genes

TUBB8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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