Article

Hypermethylated Colorectal Cancer Patients Present a Myc-Driven Hypermetabolism with a One-Carbon Signature Associated to Worsen Prognosis

2024-02-08

Abstract excerpt

Colorectal cancer (CRC) is the second cause of cancer-related death where the CpG-island methylation pathways (CIMP) is associated to KRAS/BRAF mutations, two oncogenes rewiring cell metabolism, worst prognosis and resistance to classical chemotherapies. Despite this, the question of a possible metabolic rewiring in CIMPs has never been asked. Here we asked if metabolic dysregulations were associated to the methyl...

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Literature Corpus work: d98ea4b4-a8c0-5836-9c58-e6c53f312086
DOI: 10.20944/preprints202402.0487.v1

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