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Article

Inhibition of C298S mutant of human aldose reductase for antidiabetic applications: Evidence from in silico elementary mode analysis of biological network model.

Journal of cellular biochemistry - 1 Aug 2018

Khan Saif, Bhardwaj Tulika, Somvanshi Pallavi, Mandal Raju K, Dar Sajad A, Jawed Arshad, Wahid Mohd, Akhter Naseem, Lohani Mohtashim, Alouffi S, Haque Shafiul

Abstract excerpt

Human aldose reductase (hAR) is the key enzyme in sorbitol pathway of glucose utilization and is implicated in the etiology of secondary complications of diabetes, such as, cardiovascular complications, neuropathy, nephropathy, retinopathy, and cataract genesis. It reduces glucose to sorbitol in the presence of NADPH and the major cause of diabetes complications could be the change in the osmotic pressure due to...

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PMID: 29693278
DOI: 10.1002/jcb.26904

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