Article
Rule-based multi-scale simulation for drug effect pathway analysis.
BMC medical informatics and decision making - 1 Jan 2013
Hwang Woochang, Hwang Yongdeuk, Lee Sunjae, Lee Doheon
Abstract excerpt
BACKGROUND: Biological systems are robust and complex to maintain stable phenotypes under various conditions. In these systems, drugs reported the limited efficacy and unexpected side-effects. To remedy this situation, many pharmaceutical laboratories have begun to research combination drugs and some of them have shown successful clinical results. Complementary action of multiple compounds could increase efficacy...
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