Article

Old Target with New Vision: In Search of New Therapeutics for Diabetic Retinopathy by Selective Modulation of Aldose Reductase

2025-12-16

Abstract excerpt

Despite decades of investigation, Aldose Reductase (AR; AKR1B1) -an enzyme that plays a key role in the metabolism of glucose and other carbonyl compounds and whose hy-peractivity contributes to oxidative stress and vascular dysfunction- inhibitors have failed to translate into clinical application for Diabetic Retinopathy (DR). We argue that these failures might arise from non-selective inhibition, which does not...

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Literature Corpus work: 2d6a3313-b1bd-584d-9ded-5c4a7d78d9f2
DOI: 10.20944/preprints202512.1408.v1

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