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Dauricine Mitigates Hypoxia through Targeting ESR1, PIK3CA, and MTOR: A Network Pharmacology and Molecular Dynamics Simulation Investigation

2026-05-05

Abstract excerpt

Hypoxia is a prevalent pathophysiological condition. Prolonged exposure to hypobaric hypoxia can lead to maladaptation, increasing the risk of chronic hypoxic diseases such as high-altitude polycythemia (HAPC). Dauricine, an alkaloid derived from the root of Menispermum dauricum DC, has been demonstrated to possess anti-hypoxic properties; however, its underlying molecular mechanisms remain elusive. In this study,...

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Literature Corpus work
9fb5b43f-433e-5d63-a4fc-bd8c6558bea5
DOI
10.20944/preprints202605.0242.v1
Open publication

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Dauricine Mitigates Hypoxia through Targeting ESR1, PIK3CA, and MTOR: A Network Pharmacology and Molecular Dynamics Simulation InvestigationDOI 10.20944/preprints202605.0242.v1
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