Article
Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches.
Frontiers in immunology - 1 Jan 2018
Georgiev Hristo, Ravens Inga, Papadogianni Georgia, Halle Stephan, Malissen Bernard, Loots Gabriela G, Förster Reinhold, Bernhardt Günter
Abstract excerpt
Follicular helper (TFH) and regulatory (TFR) cells are critical players in managing germinal center (GC) reactions that accomplish effective humoral immune responses. Transcriptome analyses were done comparing gene regulation of TFH and TFR cells isolated from Peyer's Patches (PP) and immunized peripheral lymph nodes (pLNs) revealing many regulatory patterns common to all follicular cells. However, in contrast to...
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