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Article

Spatial distribution and function of T follicular regulatory cells in human lymph nodes.

The Journal of experimental medicine - 4 Jun 2018

Sayin Ismail, Radtke Andrea J, Vella Laura A, Jin Wenjie, Wherry E John, Buggert Marcus, Betts Michael R, Herati Ramin S, Germain Ronald N, Canaday David H

Abstract excerpt

T follicular regulatory (Tfr) cells are a population of CD4+ T cells that express regulatory T cell markers and have been shown to suppress humoral immunity. However, the precise mechanisms and location of Tfr-mediated suppression in the lymph node (LN) microenvironment are unknown. Using highly multiplexed quantitative imaging and functional assays, we examined the spatial distribution, suppressive function, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29769249
DOI: 10.1084/jem.20171940
PMCID: PMC5987920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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