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Article

The Pathogenic Role of CD4+ Tissue-Resident Memory T Cells Bearing T Follicular Helper-Like Phenotype in Pemphigus Lesions.

The Journal of investigative dermatology - 1 Sept 2021

Zou Yaru, Yuan Huijie, Zhou Shengru, Zhou Yun, Zheng Jie, Zhu Haiqin, Pan Meng

Abstract excerpt

In skin lesions caused by pemphigus, a group of life-threatening autoimmune bullous diseases, an over-representation of CD4+ tissue-resident memory T (TRM) cells was found. We sought to investigate the contributions of CD4+ TRM cells to the severity and refractoriness of pemphigus and their role in local immunological pathogenesis. Our data showed that CD4+ TRM cells accumulated significantly in pemphigus skin...

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PMID: 33741391
DOI: 10.1016/j.jid.2021.01.030

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