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Article

Complementary charge-based interaction between the ribosomal-stalk protein L7/12 and IF2 is the key to rapid subunit association.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 2018

Ge Xueliang, Mandava Chandra Sekhar, Lind Christoffer, Åqvist Johan, Sanyal Suparna

Abstract excerpt

The interaction between the ribosomal-stalk protein L7/12 (L12) and initiation factor 2 (IF2) is essential for rapid subunit association, but the underlying mechanism is unknown. Here, we have characterized the L12-IF2 interaction on Escherichia coli ribosomes using site-directed mutagenesis, fast kinetics, and molecular dynamics (MD) simulations. Fifteen individual point mutations were introduced into the...

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Identifiers

PMID: 29686090
DOI: 10.1073/pnas.1802001115
PMCID: PMC5939111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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