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Article

Control of phosphate release from elongation factor G by ribosomal protein L7/12.

The EMBO journal - 21 Dec 2005

Savelsbergh Andreas, Mohr Dagmar, Kothe Ute, Wintermeyer Wolfgang, Rodnina Marina V

Abstract excerpt

Ribosomal protein L7/12 is crucial for the function of elongation factor G (EF-G) on the ribosome. Here, we report the localization of a site in the C-terminal domain (CTD) of L7/12 that is critical for the interaction with EF-G. Single conserved surface amino acids were replaced in the CTD of L7/12. Whereas mutations in helices 5 and 6 had no effect, replacements of V66, I69, K70, and R73 in helix 4 increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16292341
DOI: 10.1038/sj.emboj.7600884
PMCID: PMC1356325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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