Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.

RNA (New York, N.Y.) - 1 Apr 2011

Shin Byung-Sik, Acker Michael G, Kim Joo-Ran, Maher Kathryn N, Arefin Shamsul M, Lorsch Jon R, Dever Thomas E

Abstract excerpt

Translation initiation factor eIF5B promotes GTP-dependent ribosomal subunit joining in the final step of the translation initiation pathway. The protein resembles a chalice with the α-helix H12 forming the stem connecting the GTP-binding domain cup to the domain IV base. Helix H12 has been proposed to function as a rigid lever arm governing domain IV movements in response to nucleotide binding and as a molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic-Leucine Zipper Transcription Factors
Share to Eukaryotic Initiation Factor-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Eukaryotic Initiation Factors

Share to Glycine

Share to Guanosine Triphosphate

Share to Protein Structure, Secondary

Share to Ribosomes

Share to RNA, Transfer, Met

Source

Open in PubMed Open full text

Identifiers

PMID: 21335519
DOI: 10.1261/rna.2412511
PMCID: PMC3062179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.PMID 21335519Read ↗

Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.Semantic proximity Read ↗

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunitSemantic proximity Read ↗

The central core region of yeast ribosomal protein L11 is important for subunit joining and translational fidelity.Semantic proximity Read ↗

Roles of helix H69 of 23S rRNA in translation initiation.Semantic proximity Read ↗

Structural basis for the enhancement of eIF4A helicase activity by eIF4G.Semantic proximity Read ↗

Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity.Semantic proximity Read ↗

β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivo.Semantic proximity Read ↗

Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection.Semantic proximity Read ↗

Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo.Semantic proximity Read ↗

Role of helix 44 of 16S rRNA in the fidelity of translation initiation.Semantic proximity Read ↗

Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.Semantic proximity Read ↗

Mutations in the intersubunit bridge regions of 16S rRNA affect decoding and subunit-subunit interactions on the 70S ribosome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.