Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing.

Cell - 3 May 2018

Kim Charissa, Gao Ruli, Sei Emi, Brandt Rachel, Hartman Johan, Hatschek Thomas, Crosetto Nicola, Foukakis Theodoros, Navin Nicholas E

Abstract excerpt

Triple-negative breast cancer (TNBC) is an aggressive subtype that frequently develops resistance to chemotherapy. An unresolved question is whether resistance is caused by the selection of rare pre-existing clones or alternatively through the acquisition of new genomic aberrations. To investigate this question, we applied single-cell DNA and RNA sequencing in addition to bulk exome sequencing to profile...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Copy Number Variations
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoadjuvant Therapy

Share to Sequence Analysis, RNA

Share to Single-Cell Analysis

Share to Survival Analysis

Share to Triple Negative Breast Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29681456
DOI: 10.1016/j.cell.2018.03.041
PMCID: PMC6132060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing.PMID 29681456Read ↗

Identification of New Chemoresistance-Associated Genes in Triple-Negative Breast Cancer by Single-Cell Transcriptomic AnalysisSemantic proximity Read ↗

Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seqSemantic proximity Read ↗

Advances in Single-Cell Sequencing Technology and its Applications in Triple-Negative Breast CancerSemantic proximity Read ↗

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seqSemantic proximity Read ↗

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.Semantic proximity Read ↗

Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast CancerSemantic proximity Read ↗

Deciphering the gene regulatory circuitry governing chemoresistance in Triple-Negative Breast CancerSemantic proximity Read ↗

The Mutational Spectrum of Pre- and Post-Neoadjuvant Chemotherapy Triple-Negative Breast Cancers.Semantic proximity Read ↗

Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancersSemantic proximity Read ↗

Combating subclonal evolution of resistant cancer phenotypes.Semantic proximity Read ↗

Chemotherapy reshapes cellular clonal landscape via persister programs in breast cancer xenograftsSemantic proximity Read ↗

Reconstructing mutational lineages in breast cancer by multi-patient-targeted single cell DNA sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.