Article
Effect of angiotensin-converting enzyme tag single nucleotide polymorphisms on the outcome of patients with traumatic brain injury.
Pharmacogenetics and genomics - 1 Oct 2015
Dardiotis Efthimios, Paterakis Konstantinos, Siokas Vasileios, Tsivgoulis Georgios, Dardioti Maria, Grigoriadis Savas, Simeonidou Constantina, Komnos Apostolos, Kapsalaki Eftychia, Fountas Kostas, Hadjigeorgiou Georgios M
Abstract excerpt
BACKGROUND: Genetic variants appear to influence, at least to some degree, the extent of brain injury and the clinical outcome of patients who have sustained a traumatic brain injury (TBI). Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that is implicated in the regulation of blood pressure and cerebral circulation. ACE gene polymorphisms were found to regulate serum ACE enzyme activity....
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