Article

Large-Scale Structure-Based Virtual Screening Identifies Diverse K <sub>Na</sub> 1.1 (KCNT1) Potassium Channel Inhibitors

2025-10-01

Abstract excerpt

Severe drug-resistant childhood epilepsy is caused by KCNT1 gain-of-function genetic variants, resulting in increased K Na 1.1 channel activity. KCNT1 -associated epilepsy is thought to affect around 1 in 300,000 births worldwide. Current treatment for KCNT1 epilepsy only provides mild symptomatic relief and uses a cocktail of experimental medications which must be personalised for the individual and are often...

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Literature Corpus work: 2ca66225-204f-5c8c-bff0-a975a7fa0482
DOI: 10.1101/2025.09.30.679465

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