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Article

Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members.

Biochemistry - 26 Jan 2016

Prak Krisna, Kriston-Vizi Janos, Chan A W Edith, Luft Christin, Costa Joana R, Pengo Niccolo, Ketteler Robin

Abstract excerpt

Protein kinases are essential regulators of most cellular processes and are involved in the etiology and progression of multiple diseases. The cdc2-like kinases (CLKs) have been linked to various neurodegenerative disorders, metabolic regulation, and virus infection, and the kinases have been recognized as potential drug targets. Here, we have developed a screening workflow for the identification of potent CLK2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26701387
DOI: 10.1021/acs.biochem.5b01128
PMCID: PMC4730229

Genes

CLK2
CLK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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