Article
Integrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2018
Cuypers Bart, Berg Maya, Imamura Hideo, Dumetz Franck, De Muylder Géraldine, Domagalska Malgorzata A, Rijal Suman, Bhattarai Narayan Raj, Maes Ilse, Sanders Mandy, Cotton James A, Meysman Pieter, Laukens Kris, Dujardin Jean-Claude
Abstract excerpt
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases caused by L. donovani from the ISC1 genetic group, a new and emerging genotype. In this study, we perform for the first time an...
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