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Article

Mutations in an Aquaglyceroporin as a Proven Marker of Antimony Clinical Resistance in the Parasite Leishmania donovani.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 18 May 2021

Potvin Jade-Eva, Leprohon Philippe, Queffeulou Marine, Sundar Shyam, Ouellette Marc

Abstract excerpt

BACKGROUND: Antimonial drugs have long been the mainstay to treat visceral leishmaniasis. Their use has been discontinued in the Indian subcontinent because of drug resistance, but they are still clinically useful elsewhere. The goal of this study was to find markers of antimony resistance in Leishmania donovani clinical isolates and validate experimentally their role in resistance. METHODS: The genomes of...

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Identifiers

PMID: 32827255
DOI: 10.1093/cid/ciaa1236
PMCID: PMC8130028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in an Aquaglyceroporin as a Proven Marker of Antimony Clinical Resistance in the Parasite Leishmania donovani.PMID 32827255Read ↗

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