Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent.

doi:10.7554/eLife.12613

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Article

Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent.

eLife - 22 Mar 2016

Imamura Hideo, Downing Tim, Van den Broeck Frederik, Sanders Mandy J, Rijal Suman, Sundar Shyam, Mannaert An, Vanaerschot Manu, Berg Maya, De Muylder Géraldine, Dumetz Franck, Cuypers Bart, Maes Ilse, Domagalska Malgorzata, Decuypere Saskia, Rai Keshav, Uranw Surendra, Bhattarai Narayan Raj, Khanal Basudha, Prajapati Vijay Kumar, Sharma Smriti, Stark Olivia, Schönian Gabriele, De Koning Harry P, Settimo Luca, Vanhollebeke Benoit, Roy Syamal, Ostyn Bart, Boelaert Marleen, Maes Louis, Berriman Matthew, Dujardin Jean-Claude, Cotton James A

Abstract excerpt

Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector-borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antimonial drugs has probably been a contributing factor in the persistence of this epidemic. Here we use whole genome sequences from 204 clinical isolates to track the...

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PMID: 27003289
DOI: 10.7554/eLife.12613
PMCID: PMC4811772

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