Article
Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent.
The Journal of infectious diseases - 1 Sept 2012
Vanaerschot Manu, Decuypere Saskia, Downing Tim, Imamura Hideo, Stark Olivia, De Doncker Simonne, Roy Syamal, Ostyn Bart, Maes Louis, Khanal Basudha, Boelaert Marleen, Schönian Gabriele, Berriman Matthew, Chappuis François, Dujardin Jean-Claude, Sundar Shyam, Rijal Suman
Abstract excerpt
The current standard to assess pentavalent antimonial (SSG) susceptibility of Leishmania is a laborious in vitro assay of which the result has little clinical value because SSG-resistant parasites are also found in SSG-cured patients. Candidate genetic markers for clinically relevant SSG-resistant parasites identified by full genome sequencing were here validated on a larger set of clinical strains. We show that...
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