Epidemiological dynamics of antimonial resistance in Leishmania donovani: genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal.

doi:10.1016/j.meegid.2006.08.005

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Article

Epidemiological dynamics of antimonial resistance in Leishmania donovani: genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2007

Laurent Thierry, Rijal Suman, Yardley Vanessa, Croft Simon, De Doncker Simonne, Decuypere Saskia, Khanal Basudha, Singh Rupa, Schönian Gabriele, Kuhls Katrin, Chappuis François, Dujardin Jean-Claude

Abstract excerpt

Pentavalent antimonials (SbV) are the first line drug against leishmaniasis worldwide, but drug resistance is increasingly reported, particularly in the Indian sub-continent, where it represents a major threat for the control of anthroponotic visceral leishmaniasis (VL). In order to understand the epidemiological dynamics of antimonial resistance in anthroponotic VL, we analysed here the population structure of...

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PMID: 17010679
DOI: 10.1016/j.meegid.2006.08.005

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