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Article

Evolution of DNAase I Hypersensitive Sites in MHC Regulatory Regions of Primates.

Genetics - 1 Jun 2018

Jin Yabin, Gittelman Rachel M, Lu Yueer, Liu Xiaohui, Li Ming D, Ling Fei, Akey Joshua M

Abstract excerpt

It has been challenging to determine the disease-causing variant(s) for most major histocompatibility complex (MHC)-associated diseases. However, it is becoming increasingly clear that regulatory variation is pervasive and a fundamentally important mechanism governing phenotypic diversity and disease susceptibility. We gathered DNase I data from 136 human cells to characterize the regulatory landscape of the MHC...

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Share to Deoxyribonuclease I
Share to Evolution, Molecular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Major Histocompatibility Complex

Share to Nucleotide Motifs

Share to Pan troglodytes

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Share to Selection, Genetic

Source

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Identifiers

PMID: 29669733
DOI: 10.1534/genetics.118.301028
PMCID: PMC5972428

Genes

MAFK
MAX
MYC
PBX3
STAT1

Provenance

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