Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.

BMC systems biology - 5 Jun 2015

Reyes-Gibby Cielito C, Yuan Christine, Wang Jian, Yeung Sai-Ching J, Shete Sanjay

Abstract excerpt

BACKGROUND: Addictions to alcohol and tobacco, known risk factors for cancer, are complex heritable disorders. Addictive behaviors have a bidirectional relationship with pain. We hypothesize that the associations between alcohol, smoking, and opioid addiction observed in cancer patients have a genetic basis. Therefore, using bioinformatics tools, we explored the underlying genetic basis and identified new...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Gene Regulatory Networks

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Opioid-Related Disorders

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 26044620
DOI: 10.1186/s12918-015-0167-x
PMCID: PMC4456775

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.PMID 26044620Read ↗

Pathways and networks-based analysis of candidate genes associated with nicotine addiction.Semantic proximity Read ↗

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholismSemantic proximity Read ↗

An emerging multi-omic understanding of the genetics of opioid addictionSemantic proximity Read ↗

Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.Semantic proximity Read ↗

Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association dataSemantic proximity Read ↗

Genome-wide association study identifies common genetic risk factors for alcohol, heroin and methamphetamine dependenceSemantic proximity Read ↗

Functional modular networks identify the pivotal genes associated with morphine addiction and potential drug therapiesSemantic proximity Read ↗

Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use.Semantic proximity Read ↗

Human Genetics of Addiction: New Insights and Future Directions.Semantic proximity Read ↗

Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies.Semantic proximity Read ↗

Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence.Semantic proximity Read ↗

Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.