Article
Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach.
Molecular psychiatry - 1 Nov 2004
Ogden C A, Rich M E, Schork N J, Paulus M P, Geyer M A, Lohr J B, Kuczenski R, Niculescu A B
Abstract excerpt
Identifying genes for bipolar mood disorders through classic genetics has proven difficult. Here, we present a comprehensive convergent approach that translationally integrates brain gene expression data from a relevant pharmacogenomic mouse model (involving treatments with a stimulant--methamphetamine, and a mood stabilizer--valproate), with human data (linkage loci from human genetic studies, changes in...
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