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Article

Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.

Molecular psychiatry - 1 Jul 2024

Koller Dora, Friligkou Eleni, Stiltner Brendan, Pathak Gita A, Løkhammer Solveig, Levey Daniel F, Zhou Hang, Hatoum Alexander S, Deak Joseph D, Kember Rachel L, Treur Jorien L, Kranzler Henry R, Johnson Emma C, Stein Murray B, Gelernter Joel, Polimanti Renato

Abstract excerpt

Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying the comorbidity between chronic pain and SUDs will lead to a greater understanding of their biology. Genome-wide association statistics were obtained from the UK Biobank for multisite chronic pain (MCP, Neffective = 387,649) and from the Million Veteran...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38355787
DOI: 10.1038/s41380-024-02446-3
PMCID: PMC11324857

Genes

CADM2
IHO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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