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The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

17 Apr 2018

Abstract excerpt

A human immunodeficiency virus type-1 (HIV-1) vaccine which is able to effectively prevent infection would be the most powerful method of extinguishing pandemic of the acquired immunodeficiency syndrome (AIDS). Yet, achieving such vaccine remains great challenges. The membrane-proximal external region (MPER) is a highly conserved region of the envelope glycoprotein (Env) gp41 subunit near the viral envelope...

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PMID: 29667004
DOI: 10.1007/s13238-018-0534-7

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