Article
Targeting antibody responses to the membrane proximal external region of the envelope glycoprotein of human immunodeficiency virus.
PloS one - 1 Jan 2012
Kamdem Toukam Donatien, Tenbusch Matthias, Stang Alexander, Temchura Vladimir, Storcksdieck Genannt Bonsmann Michael, Grewe Bastian, Koch Stefanie, Meyerhans Andreas, Nchinda Godwin, Kaptue Lazare, Uberla Klaus
Abstract excerpt
Although human immunodeficiency type 1 (HIV-1) infection induces strong antibody responses to the viral envelope glycoprotein (Env) only a few of these antibodies possess the capacity to neutralize a broad range of strains. The induction of such antibodies represents an important goal in the development of a preventive vaccine against the infection. Among the broadly neutralizing monoclonal antibodies discovered...
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