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Article

Importance of the membrane-perturbing properties of the membrane-proximal external region of human immunodeficiency virus type 1 gp41 to viral fusion.

Journal of virology - 1 Jun 2008

Vishwanathan Sundaram A, Hunter Eric

Abstract excerpt

The membrane-proximal external region (MPER; K(665)WASLWNWFNITNWLWYIK(683)) of the human immunodeficiency virus type 1 (HIV-1) gp41 ectodomain plays a critical role in envelope glycoprotein-mediated fusion. In addition, the epitopes of important neutralizing antibodies (2F5, Z13, and 4E10) and the sequence of the peptide fusion inhibitor T20 overlap this conserved region. The MPER has an unusually high percentage...

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Identifiers

PMID: 18353966
DOI: 10.1128/JVI.00305-08
PMCID: PMC2395175

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