Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes.

Nature chemical biology - 1 May 2020

Xiao Tianshu, Frey Gary, Fu Qingshan, Lavine Christy L, Scott David A, Seaman Michael S, Chou James J, Chen Bing

Abstract excerpt

Combination antiretroviral therapy has transformed HIV-1 infection, once a fatal illness, into a manageable chronic condition. Drug resistance, severe side effects and treatment noncompliance bring challenges to combination antiretroviral therapy implementation in clinical settings and indicate the need for additional molecular targets. Here, we have identified several small-molecule fusion inhibitors, guided by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4 Antigens
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Polarization

Share to HIV Envelope Protein gp41

Share to Hydrophobic and Hydrophilic Interactions

Share to Small Molecule Libraries

Share to Surface Plasmon Resonance

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 32152540
DOI: 10.1038/s41589-020-0496-y
PMCID: PMC7723321

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes.PMID 32152540Read ↗

The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospectsSemantic proximity Read ↗

Disruption of helix-capping residues 671 and 674 reveals a role in HIV-1 entry for a specialized hinge segment of the membrane proximal external region of gp41.Semantic proximity Read ↗

Cholesterol-Dependent Membrane Fusion Induced by the gp41 Membrane-Proximal External Region–Transmembrane Domain Connection Suggests a Mechanism for Broad HIV-1 NeutralizationSemantic proximity Read ↗

HIV-1 Entry and Membrane Fusion InhibitorsSemantic proximity Read ↗

Global Increases in Human Immunodeficiency Virus Neutralization Sensitivity Due to Alterations in the Membrane-Proximal External Region of the Envelope Glycoprotein Can be Minimized by Distant State 1-Stabilizing ChangesSemantic proximity Read ↗

A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target.Semantic proximity Read ↗

Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State.Semantic proximity Read ↗

The Conformational States of the HIV-1 Envelope GlycoproteinsSemantic proximity Read ↗

Neutralizing Antibodies Targeting HIV-1 gp41.Semantic proximity Read ↗

Global Increases in Human Immunodeficiency Virus Neutralization Sensitivity Due to Alterations in the Membrane-Proximal External Region of the Envelope Glycoprotein Can Be Minimized by Distant State 1-Stabilizing ChangesSemantic proximity Read ↗

HIV-1 Envelope Conformation, Allostery, and DynamicsSemantic proximity Read ↗

Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external regionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.