Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neutralizing Antibodies Targeting HIV-1 gp41.

Viruses - 23 Oct 2020

Caillat Christophe, Guilligay Delphine, Sulbaran Guidenn, Weissenhorn Winfried

Abstract excerpt

HIV-1 vaccine research has obtained an enormous boost since the discovery of many broadly neutralizing antibodies (bnAbs) targeting all accessible sites on the HIV-1 envelope glycoprotein (Env). This in turn facilitated high-resolution structures of the Env glycoprotein in complex with bnAbs. Here we focus on gp41, its highly conserved heptad repeat region 1 (HR1), the fusion peptide (FP) and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Vaccines
Share to Antibodies, Neutralizing
Share to Epitopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Antibodies

Share to HIV Envelope Protein gp41

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 33114242
DOI: 10.3390/v12111210
PMCID: PMC7690876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neutralizing Antibodies Targeting HIV-1 gp41.PMID 33114242Read ↗

Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma MembraneSemantic proximity Read ↗

The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospectsSemantic proximity Read ↗

Structural Characterization of HIV gp41 with the Membrane-proximal External RegionSemantic proximity Read ↗

Antibodies Targeting the Envelope of HIV-1.Semantic proximity Read ↗

The complex antigenicity of a small external region of the C-terminal tail of the HIV-1 gp41 envelope protein: a lesson in epitope analysis.Semantic proximity Read ↗

Role of HIV membrane in neutralization by two broadly neutralizing antibodies.Semantic proximity Read ↗

CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activitySemantic proximity Read ↗

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodiesSemantic proximity Read ↗

Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed InhibitorsSemantic proximity Read ↗

Cholesterol-Dependent Membrane Fusion Induced by the gp41 Membrane-Proximal External Region–Transmembrane Domain Connection Suggests a Mechanism for Broad HIV-1 NeutralizationSemantic proximity Read ↗

A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target.Semantic proximity Read ↗

HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.