The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy

Abstract excerpt

Introduction Suspicion that host genetic factors determine variability in the course of natural HIV-1 infection deepened throughout the 1980s and early 1990s [1,2], but only relatively recently have we recognized the impact of human genetic variation on HIV/AIDS as a complex phenomenon [3–11]. As the control and prevention of HIV-1 infection with highly active antiretroviral therapy (HAART) became more widely...