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Article

A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22.

Science signaling - 17 Apr 2018

Vang Torkel, Nielsen Jimmi, Burn Garth L

Abstract excerpt

The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.

Read the complete abstract on PubMed

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Share to Autoimmune Diseases
Share to Genetic Predisposition to Disease
Share to Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Identifiers

PMID: 29666305
DOI: 10.1126/scisignal.aat0936

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22.PMID 29666305Read ↗

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.Semantic proximity Read ↗

Genetic Polymorphism of PTPN22 in Autoimmune Diseases: A Comprehensive Review.Semantic proximity Read ↗

The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.Semantic proximity Read ↗

Regulation of T Cell Signaling and Immune Responses by PTPN22.Semantic proximity Read ↗

Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease.Semantic proximity Read ↗

PTPN22: the archetypal non-HLA autoimmunity gene.Semantic proximity Read ↗

Autoimmunity associated allele of tyrosine phosphatase gene <i>PTPN22</i> enhances anti-viral immunitySemantic proximity Read ↗

The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.Semantic proximity Read ↗

<i>PTPN22</i>: Its role in SLE and autoimmunitySemantic proximity Read ↗

The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human.Semantic proximity Read ↗

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.Semantic proximity Read ↗

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