Article
Modeling and molecular dynamics of HPA-1a and -1b polymorphisms: effects on the structure of the β3 subunit of the αIIbβ3 integrin.
PloS one - 1 Jan 2012
Jallu Vincent, Poulain Pierre, Fuchs Patrick F J, Kaplan Cecile, de Brevern Alexandre G
Abstract excerpt
BACKGROUND: The HPA-1 alloimmune system carried by the platelet integrin αIIbβ3 is the primary cause of alloimmune thrombocytopenia in Caucasians and the HPA-1b allele might be a risk factor for thrombosis. HPA-1a and -1b alleles are defined by a leucine and a proline, respectively, at position 33 in the β3 subunit. Although the structure of αIIbβ3 is available, little is known about structural effects of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.