Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of the -RPVR- Propeptide Motif at C-Terminal of the Aα Chain Is Associated with Decreased Fibrinogen Expression.

Thrombosis and haemostasis - 1 Jan 2018

Brennan Stephen O, Laurie Andrew D

Abstract excerpt

No abstract is available from the source.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Afibrinogenemia
Share to Carboxypeptidases
Share to Fibrinogen
Share to Golgi Apparatus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Hydrolysis

Share to Prealbumin

Share to Protein Denaturation

Source

Identifiers

PMID: 29310141
DOI: 10.1160/TH17-08-0578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of the -RPVR- Propeptide Motif at C-Terminal of the Aα Chain Is Associated with Decreased Fibrinogen Expression.PMID 29310141Read ↗

Exon skipping and aberrant signal peptide cleavage produce novel fibrinogen with an Aα chain lacking the first 42 residues.Semantic proximity Read ↗

Extension of the Human Fibrinogen Database with Detailed Clinical Information-The αC-Connector Segment.Semantic proximity Read ↗

Human fibrinogen--structural variants and functional sites.Semantic proximity Read ↗

Low expression of truncated Aalpha chain variant in circulating fibrinogen.Semantic proximity Read ↗

Identification of a novel splicing mutation in the fibrinogen Aalpha chain gene leading to hypofibrinogenaemia in a Chinese pedigree.Semantic proximity Read ↗

Fibrinogen Milano XIII (Aalpha 19 Arg-->Gly): a dysfunctional variant with an amino acid substitution in the N-terminal polymerization site.Semantic proximity Read ↗

Substitution (γ335Trp→Arg) in fibrinogen Fremantle causes diminished γ chain expression and increased sialic acid content.Semantic proximity Read ↗

Novel fibrinogen (B β401Gly→Val) presents as dys- or hypodysfibrinogenaemia due to alterations in sialic acid content.Semantic proximity Read ↗

Hypodysfibrinogenemia causing mild bleeding and thrombotic complications in a compound heterozygote of AalphaIVS4+1G>T mutation and Aalpha4841delC truncation (Aalpha(Perth)).Semantic proximity Read ↗

Recurrent VTE in a heterozygote of the fibrinogen Aα IVS4+1G>T and Aα p.Arg168Ter mutation.Semantic proximity Read ↗

Novel genetic regulators of fibrinogen synthesis identified by an in vitro experimental platformSemantic proximity Read ↗

Adjacent substitutions (γ352Gly→Cys and 353Thr→Pro) in fibrinogen Ilam cause diminished γ chain expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.