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Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunities

7 Apr 2022

Abstract excerpt

Lysine succinylation (Ksuc) is a novel protein post-translational modification (PTM) wherein a succinyl group modifies a lysine residue. Ksuc leads to significant chemical and structural changes to the modified protein. Recent studies have shown that Ksuc might play an important role in organism physiology and some pathophysiological processes, such as tumorigenesis and metabolic diseases. To provide an...

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PMID: 37397549
DOI: 10.1016/j.gendis.2022.03.009

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